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KMID : 0360220210620040463
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Journal of the Korean Ophthalmological Society
2021 Volume.62 No. 4 p.463 ~ p.471
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Short-term Changes in the Tear Matrix Metalloproteinase 9 Level and Ocular Surface Discomfort after Cataract Surgery
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Lee Seung-Hyeun
Chun Yeoun-Sook
Moon Nam-Ju
Kim Kyoung-Woo
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Abstract
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Purpose: We explored changes in the various clinical parameters of dry eye disease (DED), including the tear matrix metalloproteinase9 (MMP-9) level, soon after cataract surgery. We sought correlations between such changes and ocular surfacediscomfort.
Methods: In 106 patients (106 eyes) who underwent cataract surgery, we evaluated meibomian gland dysfunction, tear secretion,corneal sensitivity, tear break-up time, corneal erosion status, the Sjogren’s International Collaborative Clinical Alliance(SICCA) ocular staining score, tear osmolarity, the tear MMP-9 level, and the ocular surface disease index (OSDI) before, and1 week and 1 month after surgery. All eyes were instilled with topical moxifloxacin, a steroid, and a non-steroidal anti-inflammatorydrug daily for 1 month postoperatively. The 1-month delta OSDI scores correlated with the 1-month delta DEDparameters. We compared the latter parameters between patients in whom the MMP-9 level decreased (MMP-9-decreasedgroup) at 1 month with those in whom it did not (MMP-9-not decreased group).
Results: Overall, 89.5% of total patients exhibited preoperative DED. The tear MMP-9 level fell at 1 month postoperatively, tearsecretion (evaluated using the Schirmer I test) decreased at 1 week, and the OSDI scores fell at both 1 week and 1 month. Wefound no significant correlation between the 1-month delta OSDI scores and the 1-month delta DED parameters. The 1-monthOSDI score fell to a significantly greater extent in the MMP-9-decreased group.
Conclusions: Routine, local anti-inflammatory treatment after cataract surgery may briefly reduce the tear MMP-9 level and ocularsurface discomfort.
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KEYWORD
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Anti-inflammation, Cataract surgery, Dry eye disease, Matrix metalloproteinase 9, Ocular surface disease index
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